Round of 32 draw pots
Seeded teams
Liverpool FC, FC Viktoria Plzeň, şikebahçe SK, FC Girondins de Bordeaux, FC Steaua Bucureşti, FC Dnipro Dnipropetrovsk, KRC Genk, FC Rubin Kazan, Olympique Lyonnais, S.S. Lazio, FC Metalist Kharkiv, Hannover 96, Chelsea FC*, CFR 1907 Cluj*, Olympiacos FC*, SL Benfica*.

Unseeded teams
FC Anji Makhachkala, Club Atlético de Madrid, VfL Borussia Mönchengladbach, Newcastle United FC, VfB Stuttgart, SSC Napoli, FC Basel 1893, FC Internazionale Milano, AC Sparta Praha, Tottenham Hotspur FC, Bayer 04 Leverkusen, Levante UD, FC Dynamo Kyiv*, FC Zenit St Petersburg*, AFC Ajax*, FC BATE Borisov*.

*Transferred from the UEFA Champions League